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Voltage-dependent L-type calcium channel subunit alpha-1D (Cav1.3)
- Target
- Cav1.3
- Molecular classification
- Ion channel, Voltage-gated Calcium Channel, L-Type Calcium Channel
01
Overview
The voltage-dependent L-type calcium channel subunit alpha-1D, also known as Cav1.3, is a pore-forming subunit of the L-type, voltage-gated calcium channel family. It mediates the entry of calcium ions into excitable cells and plays a crucial role in various physiological processes including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Mutations or dysfunctions have been linked to disorders such as familial sinus node dysfunction and focal idiopathic epilepsy; there may also be associations with autism spectrum disorder or primary aldosteronism.
- Other names
- CACNA1D
02
Mechanism of action
Calcium channel blockade
03
Biological functions
Calcium ion influxMuscle contractionNeurotransmitter releaseHormone secretionGene expressionCell motilityCell divisionCell deathCardiac pacemaking
04
Disease associations
Familial sinus node dysfunctionFocal idiopathic epilepsyAutism spectrum disorder (potential)Primary aldosteronism (potential)
05
Interacting drugs
Nifedipine
2 more in the full profile.
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