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Voltage-dependent L-type calcium channel subunit alpha-1S (Cav1.1)
- Target
- Cav1.1
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The voltage-dependent L-type calcium channel subunit alpha-1S (Cav1.1 / CACNA1S) is a pore-forming subunit of the L-type voltage-gated calcium channel complex predominantly found in skeletal muscle. It is essential for excitation-contraction coupling in skeletal muscle fibers. Mutations or dysfunctions are linked to hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.
- Other names
- CACNA1SCACNL1A3CCHL1A3HOKPP/HOKPP1MHS5TTPP1Dihydropyridine receptor (DHPR)Calcium channel, voltage-dependent, L type, alpha 1S subunit
02
Mechanism of action
Dihydropyridines (e.g., nifedipine) block the channel pore, preventing calcium influx.
03
Biological functions
Voltage-gated calcium channel activityCalmodulin bindingPositive regulation of muscle contractionCalcium ion import across plasma membraneExcitation-contraction coupling
04
Disease associations
Hypokalemic periodic paralysisThyrotoxic periodic paralysisMalignant hyperthermia susceptibility
05
Safety considerations
Potential for excessive muscle relaxationCardiac side effectsDrug interactions
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