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Target intelligence / Profile preview
Voltage-dependent L-type Calcium Channel Subunit Alpha1C (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-dependent calcium channel, L-type calcium channel
01
Overview
The CACNA1C gene encodes the alpha-1C subunit of a voltage-dependent L-type calcium channel (CaV1.2). This protein forms the main pore-forming component of the channel complex, which is essential for mediating calcium ion influx into cells upon membrane depolarization. It is crucial for generating electrical signals, regulating muscle contraction, neurotransmitter release, gene expression, and cell-to-cell communication. Dysregulation is associated with cardiac arrhythmias and psychiatric disorders.
- Other names
- CACNA1CCACH2CACN2TSLQT8
02
Mechanism of action
L-type calcium channel blocker
03
Biological functions
Calcium ion influxGenerating electrical signalsMuscle contractionNeurotransmitter releaseGene expression regulationCell-to-cell communicationCardiac conduction system functionNeurotransmission
04
Disease associations
Timothy SyndromeLong QT Syndrome Type 8Short QT SyndromeBipolar disorderSchizophreniaCardiac arrhythmia
05
Safety considerations
Cardiac arrhythmiasHypotension
06
Interacting drugs
Dihydropyridines
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