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Voltage-dependent N-type Calcium Channel (CaV2.2)
- Target
- CaV2.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The voltage-dependent N-type calcium channel (CaV2.2) is a high-voltage-activated calcium channel primarily found in neurons and neuroendocrine cells. It plays a crucial role in neurotransmitter release at presynaptic terminals and is involved in pain pathways, synaptic transmission, and other calcium-dependent cellular processes. The channel is formed by the α1B subunit and modulated by auxiliary subunits. Selective blockers like ω-conotoxins are used for pain management targeting these channels.
- Other names
- N-type calcium channelCACNA1B
02
Mechanism of action
Blockage of N-type calcium channels, preventing calcium influx and reducing neurotransmitter release, particularly in pain pathways.
03
Biological functions
Calcium ion import across plasma membraneNeurotransmitter secretion/synaptic transmissionResponse to pain stimuliRegulation of heart contractionRegulation of blood pressureSynaptogenesis
04
Disease associations
Chronic pain
05
Safety considerations
Potential for neurological side effects due to widespread expression in the nervous system.Cardiac side effects should be considered due to involvement in heart contraction.
06
Interacting drugs
ω-conotoxin-GVIA
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