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Target intelligence / Profile preview
Voltage-dependent N-type calcium channel subunit alpha‑1B (CACNA1B)
- Target
- CACNA1B
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The CACNA1B gene encodes the alpha-1B subunit of the voltage-dependent N-type calcium channel (Cav2.2), a key component for calcium ion entry into excitable cells like neurons. This channel plays a critical role in synaptic transmission, hormone secretion, and other calcium-dependent processes. Dysregulation or mutations in CACNA1B are implicated in various neurological disorders including epileptic encephalopathies and neurodevelopmental disorders, as well as cancer.
- Other names
- BIIICACNL1A5CACNNCav2.2DYT23NEDNEH
02
Mechanism of action
Calcium channel blockade
03
Biological functions
Calcium ion transportChemical synaptic transmissionTransmembrane transportMembrane depolarization during action potentialLocomotory behaviorNeurotransmissionSecretionGene expression regulation
04
Disease associations
Neurodevelopmental disorderSeizuresEpileptic encephalopathyBreast cancer
05
Safety considerations
Potential for neurological side effects due to widespread expression in the nervous system
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