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Voltage-dependent N-type calcium channel subunit alpha-1B (Cav2.2)
- Target
- Cav2.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The voltage-dependent N-type calcium channel subunit alpha-1B (Cav2.2) is the pore-forming subunit of N-type voltage-sensitive calcium channels. These channels are critical for calcium influx into excitable cells, mediating neurotransmitter release, muscle contraction, hormone secretion, and other processes. They are implicated in pain signaling and are targets for analgesic drug development.
- Other names
- CACNA1BBIIICACNL1A5CACNNDYT23calcium voltage-gated channel subunit alpha1 B
02
Mechanism of action
Inhibition of calcium influx through N-type voltage-gated calcium channels.
03
Biological functions
Neurotransmitter releaseMuscle contractionHormone secretionGene expression regulationCell motilityCell divisionSynaptic transmissionNeuron migrationCalcium signaling
04
Disease associations
Dystonia (DYT23)EpilepsyNeuropathic pain syndromesNeurodevelopmental disorders
05
Safety considerations
Potential for off-target effects on other calcium channels.Neurological side effects
06
Interacting drugs
Omega-conotoxin GVIA
1 more in the full profile.
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