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Target intelligence / Profile preview
Voltage-dependent sodium channel protein type II subunit alpha (NaV1.2)
- Target
- NaV1.2
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The voltage-dependent sodium channel protein type II subunit alpha (NaV1.2), encoded by the SCN2A gene, is a transmembrane glycoprotein that forms the pore of voltage-gated sodium channels in excitable cells such as neurons. It mediates voltage-dependent permeability to sodium ions, allowing rapid influx of Na+ during action potentials. Dysfunction of NaV1.2 due to genetic mutations is associated with a range of neurological disorders, including epilepsy and autism spectrum disorder.
- Other names
- SCN2ASodium channel protein type 2 subunit alpha
02
Mechanism of action
Voltage-dependent sodium channel blockade
03
Biological functions
Generation and propagation of neuronal action potentialsRegulation of hippocampal replay within sharp wave ripplesMyelinationIntrinsic apoptotic signaling pathway in response to osmotic stress
04
Disease associations
Seizure disordersEpilepsyAutism spectrum disordersInfantile spasmsBipolar disorder
05
Safety considerations
Potential for cardiac arrhythmiasNeurological side effects
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