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Voltage-dependent T-type Calcium Channel (T-type Calcium Channel)
- Target
- T-type Calcium Channel
- Molecular classification
- Ion channel, Voltage-gated ion channel, Calcium channel
01
Overview
Voltage-dependent T-type calcium channels are a class of low-voltage activated (LVA) calcium channels that open transiently in response to small depolarizations of the cell membrane. They are called "T-type" because of their *transient* opening and rapid inactivation kinetics. These channels play crucial roles in regulating electrical excitability, pacemaking activity, and calcium signaling across various tissues including the heart, brain, endocrine system, smooth muscle, and bone.
- Other names
- Low-voltage activated calcium channelLVA calcium channelCav3.1Cav3.2Cav3.3
02
Mechanism of action
Channel blockers that prevent calcium influx through the T-type calcium channels.
03
Biological functions
PacemakingRegulation of neuronal excitabilityMuscle contractionHormone/Neurotransmitter releaseCalcium signaling
04
Disease associations
Cardiac arrhythmiasEpilepsyNeuropathic pain
05
Safety considerations
Side effects associated with channel blockade (e.g., mibefradil)Potential for arrhythmogenic effects
06
Interacting drugs
Nickel (Ni²⁺)
1 more in the full profile.
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