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Target intelligence / Profile preview
Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1)
- Target
- Cav3.1
- Molecular classification
- Voltage-sensitive calcium channel (VSCC), T-type calcium channel, Ion channel
01
Overview
The α1G subunit, encoded by the CACNA1G gene, forms the pore of the Cav3.1 T-type calcium channel. These channels are low-voltage activated and mediate transient calcium influx, playing a crucial role in neuronal pacemaking, thalamocortical oscillations, and regulation of slow-wave sleep. They are therapeutic targets for anti-seizure medications, particularly in absence epilepsy.
- Other names
- CACNA1GCa_v3.1
02
Mechanism of action
T-type calcium channel blocker
03
Biological functions
Calcium ion influxPacemaking activityRegulation of slow-wave sleepThalamocortical relay functionCalcium signaling
04
Disease associations
EpilepsySleep disorders
05
Interacting drugs
Mibefradil
2 more in the full profile.
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