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Target intelligence / Profile preview
Voltage-dependent T-type calcium channel subunit alpha-1I (CaV3.3)
- Target
- CaV3.3
- Molecular classification
- Ion channel, Voltage-gated calcium channel, T-type calcium channel
01
Overview
The voltage-dependent T-type calcium channel subunit alpha-1I is the pore-forming α1 subunit of a voltage-gated calcium channel, specifically the CaV3.3 type. It mediates low-voltage activated (LVA) or "T-type" calcium currents, which are characterized by their activation at relatively negative membrane potentials and rapid inactivation kinetics. It plays a role in pacemaking activity in central neurons and cardiac nodal cells, modulation of neuronal firing patterns, calcium signaling in secretory cells and vascular smooth muscle, and cell growth processes.
- Other names
- CACNA1Ialpha-1I subunitT-type calcium channel alpha 1I subunit
02
Mechanism of action
Channel blocker
03
Biological functions
Regulation of neuronal excitabilityPacemaking activityCalcium signalingHormone/neurotransmitter releaseGene expression regulationModulation of neuronal firing patterns
04
Disease associations
Neuronal excitability disorders
05
Interacting drugs
Nickel ions (Ni²⁺)
1 more in the full profile.
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