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Target intelligence / Profile preview
Voltage-gated calcium channel alpha(2)delta subunit (CACNA2D)
- Target
- CACNA2D
- Molecular classification
- Ion channel subunit, Voltage-gated calcium channel subunit, Accessory protein
01
Overview
The voltage-gated calcium channel alpha(2)delta (α2δ) subunit is an auxiliary protein component of high-voltage-activated (HVA) calcium channels, essential for Ca²⁺ influx into excitable cells. It regulates channel trafficking, surface expression, and biophysical properties. Four isoforms (α2δ-1 to α2δ-4) exist, encoded by CACNA2D1-4. The α2δ subunit influences synaptic function, neurotransmitter release and is implicated in neurological disorders like neuropathic pain and epilepsy. Gabapentinoids target α2δ-1 and α2δ-2 for pain management.
- Other names
- alpha2delta subunitα2δ subunitCACNA2D1CACNA2D2CACNA2D3CACNA2D4
02
Mechanism of action
Gabapentinoids bind to the α2δ subunit, reducing calcium influx and neurotransmitter release.
03
Biological functions
Calcium channel traffickingRegulation of calcium channel kineticsModulation of voltage-dependent activationSynaptic transmissionNeurotransmitter release
04
Disease associations
Neuropathic painEpilepsyCerebellar ataxiaPsychiatric disorders
05
Safety considerations
DizzinessSomnolencePeripheral edemaAbuse potential
06
Interacting drugs
Gabapentin
2 more in the full profile.
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