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Voltage-gated calcium channel alpha-two delta-two subunit (α2δ-2)
- Target
- α2δ-2
- Molecular classification
- Voltage-Gated Calcium Channel Subunit, Auxiliary Subunit, Calcium Channel Component
01
Overview
The voltage-gated calcium channel α2δ-2 subunit is an auxiliary subunit of voltage-gated calcium channels, crucial for modulating channel trafficking, surface expression, and biophysical properties. It enhances calcium current density, modifies channel kinetics, and plays a role in synaptic transmission and neurotransmitter release. Dysregulation is implicated in neurological disorders such as ataxia, epilepsy, and neuropathic pain. It is the target of drugs like gabapentin and pregabalin.
- Other names
- CACNA2D2Calcium channel subunit alpha2/delta2
02
Mechanism of action
Binding to the α2δ subunit of voltage-gated calcium channels, decreasing calcium influx and reducing the release of excitatory neurotransmitters
03
Biological functions
Calcium channel modulationRegulation of calcium current densityTrafficking of calcium channelsModulation of channel kineticsSynaptic transmissionRegulation of neurotransmitter release
04
Disease associations
AtaxiaEpilepsy (potential)Neuropathic pain syndromes (potential)Neuropsychiatric disorders (potential)
05
Safety considerations
DizzinessSomnolencePeripheral edemaAbuse potential
06
Interacting drugs
Gabapentin
1 more in the full profile.
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