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Voltage-gated calcium channel alpha2-delta subunit (α2δ)
- Target
- α2δ
- Molecular classification
- Auxiliary Calcium Channel Subunit, Protein Subunit
01
Overview
The voltage-gated calcium channel alpha2-delta (α2δ) subunit is an auxiliary protein component of high-voltage-activated (HVA) calcium channels. It is essential for the influx of calcium ions into excitable cells upon membrane depolarization. The α2δ subunits play a critical role in modulating the function and trafficking of these channels, thereby influencing cellular excitability and signaling. It is targeted by gabapentinoid drugs such as gabapentin and pregabalin.
- Other names
- CACNA2D1CACNA2D2CACNA2D3CACNA2D4Calcium channel subunit alpha2/delta
02
Mechanism of action
Binding to α₂δ₋₁/₂ isoforms, modulating calcium channel function and reducing calcium influx.
03
Biological functions
Modulation of calcium channel activityRegulation of calcium influxTrafficking of calcium channelsSynaptic transmissionNeuronal excitability
04
Disease associations
Neuropathic painEpilepsyCerebellar ataxiaSpike-wave epilepsyNeurological disorders
05
Interacting drugs
Gabapentin
1 more in the full profile.
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