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Target intelligence / Profile preview
Voltage-Gated Calcium Channel Protein Subunit Alpha1A (CACNA1A)
- Target
- CACNA1A
- Molecular classification
- Ion channel, Voltage-gated calcium channel, P/Q-type calcium channel
01
Overview
The voltage-gated calcium channel protein subunit alpha1A, encoded by the CACNA1A gene, is the principal pore-forming component of P/Q-type voltage-dependent calcium channels. These channels are predominantly expressed in neurons and play a critical role in mediating calcium influx upon membrane depolarization. Mutations or dysfunctions in CACNA1A are linked to several neurological disorders including familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2), spinocerebellar ataxia type 6 (SCA6), epilepsy syndromes, among others.
02
Mechanism of action
Pore-forming subunit of P/Q-type voltage-gated calcium channels, mediating calcium influx upon membrane depolarization.
03
Biological functions
Calcium ion transmembrane transportRegulation of neurotransmitter releaseSynaptic transmissionRegulation of muscle contractionGene expression regulationCell motilityCell divisionApoptosis
04
Disease associations
Familial hemiplegic migraine type 1 (FHM1)Episodic ataxia type 2 (EA2)Spinocerebellar ataxia type 6 (SCA6)Epilepsy syndromes
05
Interacting drugs
omega-agatoxin IVA
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