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Target intelligence / Profile preview
Voltage-gated calcium channel protein subunit alpha1S (Cav1.1)
- Target
- Cav1.1
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The voltage-gated calcium channel protein subunit alpha1S (Cav1.1) is the pore-forming subunit of the L-type voltage-dependent calcium channel primarily located in skeletal muscle cells. It plays a crucial role in excitation-contraction coupling by sensing membrane depolarization and mechanically interacting with the ryanodine receptor (RyR1) on the sarcoplasmic reticulum, triggering calcium release and muscle contraction. Mutations in Cav1.1 are associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis, and malignant hyperthermia susceptibility. It is a target of dihydropyridine drugs.
- Other names
- CACNL1A3CCHL1A3DHPRHOKPPMHS5
02
Mechanism of action
Calcium channel blockade
03
Biological functions
Excitation-contraction couplingCalcium signalingVoltage sensing
04
Disease associations
Hypokalemic periodic paralysisThyrotoxic periodic paralysisMalignant hyperthermia susceptibility
05
Safety considerations
Potential for muscle weakness or paralysisMalignant hyperthermia risk with certain anesthetics
06
Interacting drugs
Dihydropyridines
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