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Target intelligence / Profile preview
Voltage-gated Calcium Channel Subunit Alpha 1C (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel, CaV channel, Calcium channel
01
Overview
Voltage-gated calcium channels in vascular smooth muscle (VSM), particularly the L-type CaV1.2 channel, are key mediators of calcium influx, initiating contraction and regulating vascular tone. They are primary determinants of blood pressure and are targeted by calcium channel blockers for treating hypertension. Dysregulation is implicated in cardiovascular diseases and diabetes.
- Other names
- L-type calcium channelCACNA1CDihydropyridine receptor
02
Mechanism of action
Calcium channel blockade
03
Biological functions
Calcium ion transmembrane transportRegulation of vascular toneMuscle contractionGene expression regulation
04
Disease associations
HypertensionCardiovascular diseaseDiabetes
05
Safety considerations
HypotensionBradycardiaEdema
06
Interacting drugs
Amlodipine
3 more in the full profile.
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