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Voltage-gated calcium channel subunit alpha2delta-2 (CACNA2D2)
- Target
- CACNA2D2
- Molecular classification
- Ion channel subunit, Voltage-gated calcium channel subunit, Auxiliary subunit
01
Overview
Voltage-gated calcium channel subunit alpha₂δ₂ is an essential auxiliary component that regulates both trafficking and functional properties of high-voltage activated Ca²⁺ channels. Its modulation affects key physiological processes such as neurotransmission and muscle contraction. Clinically, it serves as a drug target for epilepsy and neuropathic pain therapies due to its interaction with gabapentinoids. Genetic alterations can result in neurological disorders including epilepsy or altered drug sensitivities.
- Other names
- alpha2delta-2 subunitCACNA2D2 protein
02
Mechanism of action
Binds to the alpha2delta-2 subunit of voltage-gated calcium channels, modulating channel function and reducing calcium influx in neurons.
03
Biological functions
Calcium channel regulationProtein traffickingSynaptic transmissionNeurotransmitter releaseModulation of calcium channel kineticsRegulation of plasma membrane density of calcium channels
04
Disease associations
Epileptic encephalopathyNeuropathic painAltered pain sensitivity
05
Safety considerations
Potential for drug interactions with gabapentinoidsSide effects associated with gabapentinoid use (e.g., dizziness, somnolence)
06
Interacting drugs
Gabapentin
3 more in the full profile.
07
Biomarkers
CACNA2D2 polymorphisms (related to opioid sensitivity)
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