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Target intelligence / Profile preview
Voltage-Gated Chloride Channel Protein (Glioma-Specific) (ClC)
- Target
- ClC
- Molecular classification
- Ion channel, Voltage-gated ion channel, Chloride channel, ClC superfamily
01
Overview
Voltage-gated chloride channels (ClC family) are integral membrane proteins that facilitate the selective passage of chloride ions across cellular membranes in response to changes in membrane potential. In gliomas, particularly malignant forms, these channels—most notably ClC-2 and ClC-3—are upregulated and play a critical role in tumor cell physiology. They mediate cell volume regulation, rapid changes in cell size/shape during division or migration, and enhance invasive migration. Their upregulation correlates with higher glioma grade and poorer patient survival, making them attractive targets for therapeutic intervention.
- Other names
- Chloride channelClC-2CLCN2ClC-3CLCN3ClC-5CLCN5
02
Mechanism of action
Blockade or genetic suppression of chloride channel activity
03
Biological functions
Cell volume regulationRegulation of cell sizeRegulation of cell shapeCell migrationCell invasionChloride transport
04
Disease associations
CancerGliomaGlioblastoma
05
Safety considerations
Potential off-target effects on chloride channels in non-tumor cellsDisruption of normal physiological chloride transportElectrolyte imbalances
06
Interacting drugs
DIDS
4 more in the full profile.
07
Biomarkers
CLCN3 expression level (prognostic)ClC-2 expression levelClC-3 expression levelClC-5 expression level
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