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Voltage-gated N-type calcium channel alpha-1B subunit (Cav2.2)
- Target
- Cav2.2
- Molecular classification
- Voltage-gated calcium channels, Ion channel, Cav2 family
01
Overview
The voltage-gated N-type calcium channel alpha-1B subunit (Cav2.2) is a high-voltage activated calcium channel predominantly expressed in neuronal tissues. It plays a critical role in neurotransmitter release and pain pathways by mediating calcium influx into nerve terminals upon membrane depolarization. It is composed of the pore-forming α1B subunit along with auxiliary subunits α2δ and β. Cav2.2 is a major target for analgesics used in severe neuropathic pain conditions.
- Other names
- CACNA1BN-type calcium channel alpha-1B subunit
02
Mechanism of action
Direct channel blockade; inhibition of calcium influx
03
Biological functions
Neurotransmitter releaseCalcium influxSynaptic vesicle fusionRegulation of neuronal excitability
04
Disease associations
Neuropathic painChronic pain
05
Safety considerations
Potential for neurological side effects due to widespread neuronal expressionCareful titration required to minimize adverse effects
06
Interacting drugs
ω-conotoxins
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