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Target intelligence / Profile preview
Voltage-gated potassium channel KCNC4 (Kv3.4)
- Target
- Kv3.4
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
The Voltage-gated potassium channel Kv3.4 is a crucial component in mediating high-frequency neuronal firing in the brain and other neural tissues. It is involved in shaping action potential duration and modulating neurotransmitter release, particularly in axons and nerve terminals. Kv3.4 channels are significant in nociceptive signaling and are known to be sensitive to both chemical and enzymatic modulators, such as protein kinase C (PKC), which can alter their inactivation properties.
- Other names
- KCNC4Kv3.4 channel
02
Mechanism of action
High voltage-activation, rapid kinetics contributing to fast A-type potassium currents, modulation by PKC phosphorylation affecting inactivation
03
Biological functions
Signal transductionRepolarization of action potentialsModulation of neurotransmitter release
04
Disease associations
Neurological disordersPain modulationNociceptive signaling
05
Safety considerations
Potential modulation issues with drugs affecting PKC activitycaution with drugs affecting ion channel function
06
Interacting drugs
4-aminopyridine
2 more in the full profile.
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