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Target intelligence / Profile preview
Voltage-gated potassium channel Kv1.5 (Kv1.5)
- Target
- Kv1.5
- Molecular classification
- Ion channel, Voltage-gated potassium channel, Shaker-related K+ channel
01
Overview
Kv1.5 (KCNA5) is a voltage-gated potassium channel that belongs to the Shaker-related family. It forms tetrameric channels responsible for the ultra-rapid delayed rectifier potassium current (I_{Kur}), which is crucial for repolarizing cardiac action potentials, particularly in atrial tissue. It also plays a role in regulating resting membrane potential in pulmonary artery smooth muscle and may influence insulin secretion in pancreatic beta cells. Kv1.5 is implicated in diseases such as atrial fibrillation, sudden cardiac death, and pulmonary arterial hypertension, making it a target for antiarrhythmic drug development, particularly for treating atrial fibrillation.
- Other names
- KCNA5Potassium voltage-gated channel subfamily A member 5Shaker-related subfamily member 5Kv1.5[3][8]
02
Mechanism of action
Blockade of Kv1.5 channels
03
Biological functions
Regulation of membrane potentialCardiac action potential repolarizationRegulation of vascular toneRegulation of insulin secretion
04
Disease associations
Atrial fibrillationSudden cardiac deathPulmonary arterial hypertensionCancer
05
Safety considerations
Potential for proarrhythmic effects (though less than ventricular-acting drugs)Off-target effects in other tissues
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