Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Voltage-gated potassium channel Kv7 (Kv7 channels)
- Target
- Kv7 channels
- Molecular classification
- Ion channel
01
Overview
Kv7 channels are a family of voltage-gated potassium channels encoded by KCNQ genes, playing crucial roles in regulating neuronal excitability and maintaining resting membrane potential. They are involved in various physiological processes and are therapeutic targets for conditions like epilepsy and cardiac arrhythmias. Kv7 channels are activated at subthreshold potentials and are composed of Kv7.1 to Kv7.5 subunits, with Kv7.2-7.5 expressed in the nervous system. Mutations in these channels can lead to severe disorders, making them important targets for drug development.
- Other names
- KCNQ channelsM-type potassium channels
02
Mechanism of action
Activation of Kv7 channels to reduce neuronal excitability; Modulation of voltage dependence of channel activation
03
Biological functions
Regulation of neuronal excitabilityMaintenance of resting membrane potentialControl of action potential threshold and firing frequencyInduction of afterhyperpolarization
04
Disease associations
EpilepsyCardiac arrhythmiaDeafnessNeuropsychiatric disorders
05
Safety considerations
Potential impact on cardiac function due to Kv7.1's role in cardiac action potentials
06
Interacting drugs
Retigabine
2 more in the full profile.
07
Biomarkers
Mutations in KCNQ genes (e.g., KCNQ2 for developmental and epileptic encephalopathy)
Beyond the preview
Go deeper on Voltage-gated potassium channel Kv7 (Kv7 channels).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Voltage-gated potassium channel Kv7 (Kv7 channels).