Target intelligence / Profile preview

Voltage-gated Potassium Channel Subfamily A Member 1 (Kv1.1)

Target: Kv1.1
Molecular classification: Ion channel, Voltage-gated potassium channel, Shaker-related family

Overview

Voltage-gated potassium channel Kv1.1 is a key regulator of neuronal excitability, primarily expressed in the central nervous system. It contributes to action potential repolarization and controls neuronal firing frequency. Mutations or autoimmune reactions against Kv1.1 can cause neurological disorders such as Episodic Ataxia type 1 and Isaacs syndrome. Channel activity is modulated by small molecules, such as niflumic acid, and is sensitive to stoichiometry/arrangement within heteromeric complexes.

Other names: KCNA1HuK1RBK1MBKHBK1HuKIAEMK

Mechanism of action

Modulation of channel gating kinetics and open probability

Biological functions

Transmembrane potassium transportRegulation of neuronal excitabilityAction potential repolarizationControl of neuronal firing frequencyRegulation of neurotransmitter releaseModulation of neurocardiac function

Disease associations

Episodic Ataxia type 1Isaacs syndromeDevelopmental epileptic encephalopathies

Safety considerations

Potential for neurological disorders due to altered channel functionAutoimmune reactions targeting Kv1.1 channels

Interacting drugs

Niflumic acid

1 more in the full profile.

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