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Target intelligence / Profile preview
Voltage-gated potassium channel subfamily C member 3 (Kv3.3)
- Target
- Kv3.3
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
Voltage-gated potassium channel subfamily C member 3 (KCNC3 / Kv3.3) is a protein that forms part of the voltage-gated potassium channels, crucial for regulating the electrical excitability of cells by allowing selective passage of potassium ions across cell membranes in response to changes in membrane potential. Kv3.3 is particularly important for enabling rapid repolarization of action potentials in neurons, allowing neurons—especially cerebellar Purkinje cells—to fire at high frequencies. Mutations or dysfunctions in KCNC3 have been associated with neurological disorders such as spinocerebellar ataxia type 13 (SCA13).
- Other names
- KCNC3KSHIIIDPotassium voltage-gated channel KCNC3
02
Mechanism of action
Modulation of neuronal excitability by regulating potassium ion flow across neuronal membranes.
03
Biological functions
Regulation of neuronal excitabilityControl of action potential firing rate and patternModulation of synaptic transmissionPotassium ion transmembrane transportRegulation of dendritic calcium spikes
04
Disease associations
Spinocerebellar ataxia type 13 (SCA13)Neurological disorders
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