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Target intelligence / Profile preview
Voltage-gated Potassium Channel Subfamily C Member 4 (Kv3.4)
- Target
- Kv3.4
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
KCNC4 encodes a voltage-gated potassium channel that mediates the voltage-dependent permeability of excitable membranes to potassium ions. The protein forms a potassium-selective channel that opens or closes in response to changes in membrane potential, allowing K+ ions to flow according to their electrochemical gradient. This activity is crucial for repolarizing the membrane during action potentials and contributes significantly to neuronal excitability and signal transmission. It plays an essential role in regulating action potential duration and frequency, especially for high-frequency firing neurons.
- Other names
- KCNC4KSHIIICVoltage-gated potassium channel subunit Kv3.4
02
Biological functions
Regulation of neuronal excitabilityAction potential repolarizationPotassium ion transportSignal transmission
03
Disease associations
Neurological disorders
04
Safety considerations
Potential for altered neuronal excitability
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