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Target intelligence / Profile preview
Voltage-gated potassium channel subfamily H member 2 (hERG)
- Target
- hERG
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
Voltage-gated potassium channel subfamily H member 2 (KCNH2), also known as hERG (human Ether-à-go-go-Related Gene) or Kv11.1, is a pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel. It plays a critical role in repolarizing the cardiac action potential, and dysfunction is associated with Long QT Syndrome type 2 (LQT2). Recent studies also indicate its involvement in regulating incretin hormone secretion in gut epithelial cells, suggesting potential therapeutic applications in diabetes and obesity management.
- Other names
- ERG1HERGhERG1Kv11.1Ether-a-go-go-related gene potassium channel 1Eag homolog/protein 1
02
Mechanism of action
Channel blocker; Channel modulator
03
Biological functions
Cardiac action potential repolarizationRegulation of electrical signalingRegulation of incretin hormone secretion
04
Disease associations
Long QT syndrome type 2ArrhythmiaDiabetesObesity
05
Safety considerations
Drug-induced Long QT SyndromeArrhythmia
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