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Target intelligence / Profile preview
Voltage-Gated Potassium Channel Subfamily Q Member 2 (KCNQ2)
- Target
- KCNQ2
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel
01
Overview
KCNQ2 encodes a voltage-gated potassium channel subunit (Kv7.2) essential for neuronal excitability and signal transmission. It forms part of the M-channel, regulating neuronal firing by generating the M-current. Mutations in KCNQ2 are linked to epilepsy syndromes like BFNC and EIEE7. It is blocked by compounds such as linopirdine and XE991 and activated by anticonvulsant drugs like retigabine.
- Other names
- Potassium voltage-gated channel subfamily KQT member 2Voltage-gated potassium channel subunit Kv7.2KQT-like 2Neuroblastoma-specific potassium channel subunit alpha KvLQT2BFNCBFNS1EBNEBN1ENB1EIEE7HNSPCKCNA11KVNQBHUMANKVEBN1potassium voltage-gated channel subfamily Q member 2potassium voltage-gated channel subfamily KQT member 2voltage-gated potassium channel subunit Kv7.2
02
Mechanism of action
Enhancement of KCNQ2 channel activity (e.g., by retigabine) reduces neuronal excitability and prevents seizures.
03
Biological functions
Regulation of neuronal excitabilityPotassium ion transportSignal transmission
04
Disease associations
Benign familial neonatal convulsions (BFNC/BFNS1)Early infantile epileptic encephalopathy type 7 (EIEE7)Epilepsy
05
Safety considerations
Potential for off-target effects due to broad expression in the central nervous system.Developmental delay if dysfunctional
06
Interacting drugs
Linopirdine
2 more in the full profile.
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