Target intelligence / Profile preview

Voltage-gated potassium channel subunit Kv3.1 (Kv3.1)

Target: Kv3.1
Molecular classification: Ion channel, Voltage-gated potassium channel

Overview

Kv3.1 channels are crucial for neuronal repolarization and high-frequency action potential firing, particularly in neurons requiring fast signaling and precise timing, such as those involved in auditory processing and fast-spiking interneurons. They are tetrameric structures composed of four pore-forming alpha subunits, each containing six transmembrane helices (S1–S6). Kv3.1 channelopathy has been linked to various human diseases, including epilepsy, developmental delay, and ataxia, making them potential therapeutic targets for neurological diseases.

Mechanism of action

Modulation of Kv3.1 channel conformation and function

Biological functions

Neuronal repolarizationHigh-frequency action potential firing

Disease associations

EpilepsyDevelopmental delayAtaxia

Interacting drugs

AUT5

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