Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2)
- Target
- KCNQ2
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel
01
Overview
KCNQ2 encodes the Kv7.2 subunit, a pore-forming component of voltage-gated potassium channels crucial for generating the M-current in neurons. The M-current regulates neuronal excitability by stabilizing the resting membrane potential and controlling action potential firing thresholds. Mutations in KCNQ2 are associated with neurological disorders like Benign Familial Neonatal Seizures (BFNS) due to reduced M-current function.
- Other names
- BFNCBFNS1EBN1EIEE7ENB1HNSPCKCNA11KQT-like 2KVEBN1Voltage-gated potassium channel subunit Kv7.2Potassium voltage-gated channel subfamily Q member 2Potassium voltage-gated channel, KQT-like subfamily Q member 2
02
Mechanism of action
Linopirdine and XE991 block KCNQ2 channels. Retigabine activates KCNQ2 channels.
03
Biological functions
Regulation of neuronal excitabilityStabilizing resting membrane potentialControl of action potential firing thresholdsPotassium ion transmembrane transport
04
Disease associations
Benign familial neonatal seizures (BFNS)Epileptic encephalopathies
05
Safety considerations
Potential for off-target effects due to potassium channel modulation
06
Interacting drugs
Linopirdine
2 more in the full profile.
Beyond the preview
Go deeper on Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2).