Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Voltage-Gated Sodium Channel (Non-Selective) (VGSC)
- Target
- VGSC
- Molecular classification
- Ion channel, Voltage-gated ion channel
01
Overview
Voltage-gated sodium channels are integral membrane proteins that enable the rapid influx of sodium ions into cells in response to changes in membrane potential. This process is essential for the initiation and propagation of action potentials in excitable tissues. The term "non-selective" here typically refers to channels that, while primarily selective for sodium, may also allow passage of other cations under certain conditions or experimental manipulations.
- Other names
- Sodium ChannelNav channelVoltage-dependent sodium channel
02
Mechanism of action
Channel blockade; state-dependent binding
03
Biological functions
Action potential generationNeuronal excitabilityMuscle contractionSodium ion transport
04
Disease associations
EpilepsyCardiac arrhythmiaPain syndromesNeuropathic painMyotonia
05
Safety considerations
Cardiac toxicityNeurological side effectsArrhythmia exacerbation
06
Interacting drugs
Lidocaine
6 more in the full profile.
Beyond the preview
Go deeper on Voltage-Gated Sodium Channel (Non-Selective) (VGSC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Voltage-Gated Sodium Channel (Non-Selective) (VGSC).