Target intelligence / Profile preview

Voltage-gated sodium channel alpha subunit (VGSC alpha subunit)

Target: VGSC alpha subunit
Molecular classification: Ion channel, Voltage-gated ion channel

Overview

The principal pore-forming component of voltage-gated sodium channels (VGSCs), essential for the initiation and propagation of action potentials in excitable cells. The alpha subunit alone can form a functional ion channel, but its properties can be modulated by auxiliary beta subunits.

Mechanism of action

Binding to the pore region or fenestrations between transmembrane segments, blocking Na+ influx.

Biological functions

Action potential initiationAction potential propagationElectrical signaling

Disease associations

EpilepsyCardiac arrhythmiaPain syndromes

Safety considerations

Cardiac arrhythmiasEpilepsy

Interacting drugs

Tetrodotoxin

Beyond the preview

Go deeper on Voltage-gated sodium channel alpha subunit (VGSC alpha subunit).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Voltage-gated sodium channel alpha subunit (VGSC alpha subunit).

Explore the full profile