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Target intelligence / Profile preview
Voltage-Gated Sodium Channel Alpha Subunit Nav1.7 (Nav1.7)
- Target
- Nav1.7
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Nav1.7 is a voltage-gated sodium channel alpha subunit encoded by the SCN9A gene. It is a critical component of electrical signaling in pain-sensing neurons, amplifying small depolarizations to initiate action potentials. Mutations in SCN9A are associated with pain disorders, and the channel is a target for analgesic drug development. It has also been implicated in cancer cell migration and metastasis.
- Other names
- SCN9AVoltage-gated sodium channel alpha subunit type IXNavα subunit 9Navα(IX)NaVα(IX)
02
Mechanism of action
Inhibition of sodium channel activity.
03
Biological functions
Action potential generationPain signalingNeuronal excitability
04
Disease associations
Pain disordersErythromelalgiaCongenital insensitivity to painCancerIncreased migration/invasion/metastasis
05
Safety considerations
Potential for off-target effects due to sodium channel family homology.Development of resistance to inhibitors.
06
Interacting drugs
Tetrodotoxin (TTX)
1 more in the full profile.
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