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Target intelligence / Profile preview
Voltage-gated sodium channel Nav1.2 (Nav1.2)
- Target
- Nav1.2
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Voltage-gated sodium channel Nav1.2 (encoded by the SCN2A gene) is a critical membrane protein predominantly expressed in excitatory neurons of the central nervous system (CNS). It plays a fundamental role in initiating and propagating action potentials, which are essential for neuronal communication.
- Other names
- SCN2ASodium channel protein type 2 subunit alpha
02
Mechanism of action
Channel blocking
03
Biological functions
Action potential initiationAction potential propagationNeuronal excitabilitySodium ion transport
04
Disease associations
Epilepsy syndromesAutism spectrum disorderIntellectual disability
05
Safety considerations
Potential for off-target effects on other sodium channelsCardiac or peripheral nervous system effects
06
Interacting drugs
μ-conotoxin KIIIA
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