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Target intelligence / Profile preview
Voltage-Gated Sodium Channel Nav1.5 (Nav1.5)
- Target
- Nav1.5
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Nav1.5 is a voltage-gated sodium channel primarily expressed in cardiac muscle, where it plays a critical role in the initiation and propagation of action potentials that trigger heartbeats. The channel is encoded by the SCN5A gene. Mutations or dysfunctions are linked to various inherited arrhythmia syndromes, making it a major target for antiarrhythmic therapies and genetic screening.
- Other names
- SCN5ASodium channel protein type 5 subunit alphahH1
02
Mechanism of action
Blocks sodium ion flow through the channel pore
03
Biological functions
Cardiac action potential initiation and propagationSodium ion transmembrane transportRegulation of heart rateRegulation of cardiac excitability
04
Disease associations
Long QT syndrome type 3Brugada syndromeCardiac conduction diseaseArrhythmia
05
Safety considerations
Proarrhythmic effectsDrug-induced QT prolongationRisk of sudden cardiac death in susceptible individuals
06
Interacting drugs
Flecainide
1 more in the full profile.
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