Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Voltage-Gated Sodium Channel Protein (VGSC)
- Target
- VGSC
- Molecular classification
- Ion channel, Voltage-gated ion channel
01
Overview
Voltage-gated sodium channels are critical molecular machines enabling rapid electrical signaling throughout nervous systems and other excitable tissues by mediating fast inward currents carried by sodium ions following membrane depolarization. Their structure-function relationships underpin both normal physiology and numerous disease states when mutated or pharmacologically targeted.
- Other names
- Voltage-gated sodium channelSodium channelNaV channel
02
Mechanism of action
Block or modify channel function by binding within or near the central cavity or voltage-sensing regions.
03
Biological functions
Action potential initiation and propagationSodium ion transmembrane transportElectrical signalingNeuronal excitabilityMuscle contraction
04
Disease associations
EpilepsyCardiac arrhythmiaLong QT syndromePain disordersPeriodic paralysis syndromesChannelopathy
05
Safety considerations
Cardiac arrhythmiaNeurological side effectsDrug interactions
06
Interacting drugs
Local anesthetics
4 more in the full profile.
Beyond the preview
Go deeper on Voltage-Gated Sodium Channel Protein (VGSC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Voltage-Gated Sodium Channel Protein (VGSC).