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Voltage-gated sodium channel protein type

Molecular classification: Ion channel, Voltage-gated ion channel

Overview

Voltage-gated sodium channels (VGSCs), also known as Nav channels, are large transmembrane proteins essential for the initiation and propagation of action potentials in excitable cells such as neurons, muscle cells, and cardiac tissue. Local anesthetics exert their primary effect by blocking VGSCs, preventing sodium influx during depolarization, inhibiting action potential generation and thus nerve conduction.

Other names: VGSCNav channelSodium channel

Mechanism of action

Blockade/modulation via inner pore binding, preferentially when channels are open or inactivated ("use-dependent block")

Biological functions

Initiation/propagation of action potentialsNeuronal signalingMuscle contractionPain transmissionCardiac rhythm

Disease associations

Chronic pain syndromesEpilepsyArrhythmias

Interacting drugs

Local anesthetics

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