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Target intelligence / Profile preview
Voltage-gated sodium channel protein type 10 subunit alpha (Nav1.8)
- Target
- Nav1.8
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Voltage-gated sodium channel protein type 10 subunit alpha (SCN10A / Nav1.8) is a tetrodotoxin-resistant sodium channel alpha subunit that mediates voltage-dependent sodium ion permeability in excitable membranes. It plays a critical role in the generation and propagation of action potentials, particularly in nociceptive sensory neurons involved in pain signaling. Mutations or polymorphisms in SCN10A/Nav1.8 have been linked to small fiber neuropathy and cardiac arrhythmias.
- Other names
- SCN10APN3SNShPN3FEPS2peripheral nerve sodium channel 3
02
Mechanism of action
Voltage-dependent sodium ion permeability modulation
03
Biological functions
Action potential propagationPain transmissionCardiac conduction
04
Disease associations
Small fiber neuropathyCardiac arrhythmiaPainNeuropathic painInflammatory pain
05
Safety considerations
Potential for cardiac arrhythmiasPotential for altered pain sensitivity
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