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Target intelligence / Profile preview
Voltage-gated sodium channel protein type 4 subunit alpha (Nav1.4)
- Target
- Nav1.4
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The voltage-gated sodium channel protein type 4 subunit alpha is a pore-forming transmembrane glycoprotein that constitutes the main functional component of the Nav1.4 sodium channels in skeletal muscle. It mediates rapid influx of Na⁺ ions into muscle cells during action potentials, which is essential for initiating and propagating electrical signals required for muscle contraction and relaxation. Mutations in SCN4A are linked to several neuromuscular disorders including periodic paralyses and myotonias.
- Other names
- SkM1Sodium channel protein skeletal muscle subunit alphaSodium voltage-gated channel alpha subunit 4
02
Mechanism of action
Channel blocker
03
Biological functions
Muscle contractionMembrane depolarization during action potentialSodium ion transmembrane transportSodium ion transport
04
Disease associations
Hypokalemic periodic paralysisHyperkalemic periodic paralysisParamyotonia congenitaPotassium-aggravated myotonia
05
Safety considerations
Potential for off-target effects on other sodium channelsCardiac arrhythmia (theoretical risk if inappropriately targeted)
06
Interacting drugs
Tetrodotoxin (TTX)
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