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Target intelligence / Profile preview
Voltage-gated Sodium Channel Protein Type 5 Subunit Alpha (NaV1.5)
- Target
- NaV1.5
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The voltage-gated sodium channel protein type 5 subunit alpha (NaV1.5) is a pore-forming subunit of the cardiac sodium channel, encoded by the SCN5A gene. Primarily expressed in cardiac muscle cells, it plays a critical role in generating and propagating electrical signals necessary for normal heart rhythm by mediating the fast influx of sodium ions during phase 0 of the cardiac action potential. Mutations in SCN5A are associated with various inherited arrhythmia syndromes.
- Other names
- Sodium channel protein cardiac muscle subunit alphaSodium channel protein type V subunit alphaVoltage-gated sodium channel subunit alpha Nav1.5SCN5A
02
Mechanism of action
Sodium channel blockade (modulators)
03
Biological functions
Sodium ion transmembrane transportRegulation of membrane potentialCardiac action potential generationImpulse propagation
04
Disease associations
Long QT syndrome type 3Brugada syndromeCardiac conduction diseaseAtrial fibrillationSudden infant death syndromeArrhythmia
05
Safety considerations
ArrhythmiaCardiac toxicity
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