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Target intelligence / Profile preview
Voltage-gated sodium channel protein type 9 subunit alpha (NaV1.7)
- Target
- NaV1.7
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The voltage-gated sodium channel protein type 9 subunit alpha (NaV1.7) is the pore-forming α subunit of the NaV1.7 channel, encoded by the SCN9A gene. It plays a critical role in generating and conducting action potentials in excitable cells, especially neurons involved in pain sensation (nociceptors). Mutations in SCN9A are linked to several human disorders, including paroxysmal extreme pain disorder, congenital insensitivity to pain, and anosmia.
- Other names
- SCN9ANaV1.7 alpha subunitSodium channel protein type IX alpha subunit
02
Mechanism of action
Blocker of voltage-gated sodium channels, inhibiting neuronal excitability
03
Biological functions
Action potential initiationAction potential propagationNociceptionSodium ion transport
04
Disease associations
Paroxysmal extreme pain disorderCongenital insensitivity to painAnosmia
05
Interacting drugs
Lidocaine
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