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Target intelligence / Profile preview
Voltage-Gated Sodium Channel Protein Type II Alpha Subunit (Nav1.2)
- Target
- Nav1.2
- Molecular classification
- Ion channel, Voltage-gated ion channel
01
Overview
The voltage-gated sodium channel protein type II alpha subunit, commonly abbreviated as Nav1.2, is a critical membrane protein in humans encoded by the SCN2A gene. It forms the core of a voltage-gated sodium channel complex that is essential for the initiation and propagation of action potentials in neurons. Mutations or dysfunctions in SCN2A/Nav1.2 are associated with several neurological disorders. Nav channels are targets for various drugs including local anesthetics, anticonvulsants, antiarrhythmics, as well as toxins from marine organisms that affect gating or conductance properties.
- Other names
- Sodium channel protein type 2 subunit alphaSCN2A
02
Mechanism of action
Various drugs affect gating or conductance properties of Nav1.2. Beta subunits influence channel kinetics.
03
Biological functions
Generation and propagation of neuronal action potentialsRegulation of hippocampal replay during sharp wave ripplesMyelination processesIntrinsic apoptotic signaling pathways
04
Disease associations
Benign familial infantile seizuresDevelopmental and epileptic encephalopathy 11Autism spectrum disordersInfantile spasmsBitemporal glucose hypometabolismBipolar disorder
05
Interacting drugs
Local anesthetics
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