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Target intelligence / Profile preview
Voltage-gated sodium channel protein type IX alpha subunit (NaV1.7 alpha subunit)
- Target
- NaV1.7 alpha subunit
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The voltage-gated sodium channel protein type IX alpha subunit (NaV1.7) is the pore-forming component of the NaV1.7 channel, a voltage-gated sodium channel critical for generating and conducting action potentials in excitable cells, especially nociceptors. Mutations in SCN9A, the gene encoding NaV1.7, can cause a range of pain disorders or congenital insensitivity to pain. Selective NaV1.7 blockers are being developed as analgesics.
- Other names
- SCN9ANaV1.7 alphahNaV1.7Sodium channel, voltage-gated, type IX, alpha subunit
02
Mechanism of action
Selective blockade of NaV1.7 channels, reducing sodium influx and neuronal excitability.
03
Biological functions
Action potential generationNociceptionSodium ion transportNeuronal excitability
04
Disease associations
Primary erythermalgiaParoxysmal extreme pain disorderSmall fiber neuropathyFamilial febrile seizuresGeneralized epilepsy with febrile seizures-plusCongenital insensitivity to painPain (chronic and acute)
05
Safety considerations
Potential for off-target effects on other sodium channelsCardiovascular effectsNeurological side effects
06
Interacting drugs
XEN402
1 more in the full profile.
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