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Target intelligence / Profile preview
Voltage-gated sodium channel subtype Nav1.7 (Nav1.7)
- Target
- Nav1.7
- Molecular classification
- Ion channel, Voltage-gated sodium channel
01
Overview
Nav1.7 is a voltage-gated sodium channel subtype encoded by the SCN9A gene, playing a crucial role in pain sensation. It amplifies small depolarizations in nociceptors, setting the excitability threshold for action potentials. Mutations can cause congenital insensitivity to pain or inherited pain syndromes. It is a target for novel analgesics due to its role in neuropathic and inflammatory pain, and is also implicated in certain cancers due to its role in increasing cell migration and invasion.
- Other names
- Sodium channel protein type 9 subunit alphaSCN9A
02
Mechanism of action
Selective blockade of Nav1.7 channel, affecting gating properties and sodium ion flow.
03
Biological functions
Action potential initiation and propagationNociceptionSetting excitability thresholdAmplification of generator potentials
04
Disease associations
Neuropathic painInflammatory painCongenital insensitivity to painPrimary erythromelalgiaParoxysmal extreme pain disorderCancer (metastasis)
05
Safety considerations
Potential for off-target effects on other sodium channelsDevelopment of resistanceUnforeseen effects on neuronal excitability
06
Interacting drugs
Tetrodotoxin
2 more in the full profile.
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