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Target intelligence / Profile preview
Voltage-gated sodium channel subtype Nav1.8 (Nav1.8)
- Target
- Nav1.8
- Molecular classification
- Voltage-gated ion channel, Sodium channel
01
Overview
Nav1.8 is a voltage-gated sodium channel subtype highly expressed in nociceptors and plays a critical role in pain signaling. It is tetrodotoxin-resistant and activates at more depolarized potentials with slower inactivation kinetics compared to other sodium channels. Nav1.8 is a promising target for non-opioid analgesics due to its selective expression and central role in pathological pain.
- Other names
- SCN10A
02
Mechanism of action
Selective inhibition of Nav1.8, Targeted protein degradation
03
Biological functions
Action potential generationAction potential propagationPain transmissionNociception
04
Disease associations
Chronic painInflammatory painNeuropathic painCold-induced pain
05
Safety considerations
Potential for off-target effects on related sodium channel subtypesPotential for fewer side effects compared to opioid analgesics
06
Interacting drugs
A-803467
2 more in the full profile.
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