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Target intelligence / Profile preview
Voltage-Gated T-type Calcium Channel (CaV3)
- Target
- CaV3
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The voltage-gated T-type calcium channel is a member of the voltage-gated calcium channel (VGCC) family, specifically the CaV3 subfamily. These channels are low-voltage-activated, opening in response to small depolarizations. They mediate calcium influx, influencing neuronal firing patterns, hormone secretion, and pacemaking activity in the heart. Subtypes include CaV3.1 (CACNA1G), CaV3.2 (CACNA1H), and CaV3.3 (CACNA1I). Dysregulation is implicated in epilepsy, pain, arrhythmias, and other conditions. They are characterized by low activation threshold, small conductance, and rapid kinetics.
- Other names
- T-type calcium channelCaV3.1CaV3.2CaV3.3CACNA1GCACNA1HCACNA1I
02
Mechanism of action
Inhibition of calcium ion influx through T-type calcium channels
03
Biological functions
Calcium ion influxRegulation of neuronal excitabilitySynaptic transmissionPacemaking activityHormone secretionGene expression regulation
04
Disease associations
EpilepsyNeuropathic painCardiac arrhythmiasHypertensionSleep disorders
05
Safety considerations
Potential for cardiac side effectsNeurological side effects
06
Interacting drugs
Mibefradil
2 more in the full profile.
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