Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Volume-regulated anion channel protein LRRC8A (VRAC)
- Target
- VRAC
- Molecular classification
- Ion channel
01
Overview
LRRC8A is the essential subunit of the volume-regulated anion channel (VRAC), a ubiquitously expressed ion channel in vertebrate cells. VRACs are critical for maintaining cell volume homeostasis by mediating the efflux of chloride ions and organic osmolytes in response to cell swelling. Beyond osmoregulation, VRACs participate in fluid secretion, glutamate release (notably in astrocytes), regulation of membrane potential, cell proliferation and migration, and apoptosis induction. LRRC8A-containing channels also play roles in immune responses, drug uptake (notably platinum-based chemotherapeutics), and may contribute to pathological states such as cancer progression and ischemic injury.
- Other names
- SWELL1LRRC8A
02
Mechanism of action
Mediates the efflux of chloride ions and organic osmolytes in response to cell swelling.
03
Biological functions
Cell volume regulation/RVDIon/osmolyte transportCell signalingFluid secretionGlutamate releaseRegulation of membrane potentialCell proliferationCell migrationApoptosis inductionImmune response
04
Disease associations
Cancer progression/metastasisChemotherapy resistance/sensitivityIschemia-induced neurotoxicity
05
Interacting drugs
Platinum-based chemotherapeutics
Beyond the preview
Go deeper on Volume-regulated anion channel protein LRRC8A (VRAC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Volume-regulated anion channel protein LRRC8A (VRAC).