Volume-regulated anion channel subunit LRRC8E (LRRC8E)

Volume-regulated anion channel subunit LRRC8E (LRRC8E) is an integral membrane protein and one of five LRRC8 family members (LRRC8A-E) that assemble into heteromeric hexameric channels called VRAC. These channels are critical for maintaining cell homeostasis under hypotonic stress by mediating swelling-induced efflux of chloride ions and small organic solutes. Functional VRAC channels require LRRC8A and at least one other LRRC8 isoform—often including LRRC8E—to restore native currents. VRAC serves essential roles in regulating cell volume, cell proliferation, apoptosis, neurotransmitter (such as ATP and glutamate) release, and is involved in pathophysiological responses to chemotherapeutics and cell stress. LRRC8E contributes to the heterogeneity in channel selectivity and kinetic properties and participates in specialized functions such as cGAMP transport in immune signaling.

Other names

Leucine-rich repeat-containing protein 8ELeucine rich repeat containing 8 family member EFLJ23420

Facilitation of cell volume regulation and apoptosis via anion/solute efflux; modulation of cell response to platinum-based chemotherapeutics; participant in organic solute release affecting cellular signaling