Target intelligence / Profile preview

Vomeronasal 1 receptor 35 pseudogene (VN1R35P)

Target: VN1R35P
Molecular classification: Pseudogene[5][6][7], G protein-coupled receptor pseudogene (evolutionarily classified as a member of the GPCR family, but not a functional receptor in humans)[8], Vomeronasal receptor family, class 1 (V1R) pseudogene[8]

Overview

The vomeronasal 1 receptor 35 pseudogene (VN1R35P) is a non-functional genetic element in humans, annotated as a pseudogene rather than a protein-coding gene[5][6][7]. Its evolutionary ancestors belong to the vomeronasal type-1 receptor genes, which are part of the G protein-coupled receptor (GPCR) superfamily involved in pheromone detection in other species[8]. However, pseudogenization of many vomeronasal receptor genes, including VN1R35P, has occurred in primates, resulting in nonfunctional remnants due to relaxed evolutionary selection and high rates of non-synonymous mutations[8]. This pseudogene does not produce a receptor protein and has no known physiological or disease implication in humans.

Other names: VN1R35P[5][6][7]Vomeronasal type-1 receptor 35 pseudogene (rare variant)ENSG00000228660 (Ensembl identifier)[6]HGNC:37355 (HGNC identifier)[7]

Mechanism of action

Not applicable (no drugs target this pseudogene, as it is not functional)

Biological functions

None in humans (as this pseudogene does not encode a functional protein)[6][7][8]

Disease associations

None known (no evidence for a disease association as it is non-functional in humans)

Safety considerations

None

Interacting drugs

None (no protein product, thus no known drug interactions)

Biomarkers

None reported

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