Vomeronasal type-1 receptor 2 (VN1R2)

Vomeronasal type-1 receptor 2 (VN1R2) is a member of the *type 1 vomeronasal receptor (V1R)* family, which are G protein-coupled receptors (GPCRs) predominantly expressed in the vomeronasal organ—a specialized structure within the nasal cavity of many vertebrates responsible for detecting pheromonal cues and other chemosensory stimuli[1][2]. VN1R2 is involved in the recognition of sulfated estrogens, glucuronidated estrogens, and certain steroids, playing a key role in identifying steroid-derived signals in mammals[1][2]. This receptor enables social and reproductive behaviors by facilitating the nervous system’s detection of conspecific signals and physiological status through specific ligand-receptor interactions[1][2]. No direct clinical or pharmaceutical relevance has been established for this receptor, and it is primarily of interest for studies in sensory neuroscience and animal behavior[1][2].

Other names

Vomeronasal 1 receptor 2VN1R2V1RL2hGPCR25G-protein coupled receptor GPCR25V1R-like receptor 2vomeronasal type-1 receptor 2pheromone receptorV1r-like receptor 2

no drug targeting VN1R2, mechanism relates to chemosensory transduction of steroidal ligands