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Target intelligence / Profile preview
Von Willebrand Factor
- Molecular classification
- Glycoprotein, Multimeric protein, Adhesion molecule, Coagulation factor regulator
01
Overview
Von Willebrand factor (VWF) is a large, multimeric glycoprotein found in blood plasma. It plays a central role in hemostasis by mediating platelet adhesion to sites of vascular injury and stabilizing coagulation factor VIII, which is essential for proper blood clotting. Deficiency or dysfunction of VWF leads to von Willebrand disease (VWD), characterized by impaired blood clotting and increased bleeding tendency.
02
Mechanism of action
Replacement therapy; promoting platelet adhesion and factor VIII stability
03
Biological functions
Platelet adhesionFactor VIII carrierHemostasisAngiogenesis
04
Disease associations
Von Willebrand diseaseHemophilia A (secondary deficiency)Vascular malformations
05
Safety considerations
Thrombotic events (rare)Anaphylactic reactionsTransmission of infectious agents (plasma-derived products)
06
Interacting drugs
Therapeutic human plasma-derived VWF
1 more in the full profile.
07
Biomarkers
VWF antigen levelsVWF activity assays (e.g., ristocetin cofactor activity)
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